Results
| PMID | 16046047 |
| Gene Name | IL1A |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 58 |
| Population details | 58 (43 with endometriosis, 15 without endometriosis ) |
| Sex | Female |
| Associated genes | IL-1alpha, IL-1 sRII and IL-1 Ra |
| Other associated phenotypes |
Female infertility, endometriosis |
|
Eur J Obstet Gynecol Reprod Biol. 2005 Dec 1;123(2):198-203. Epub 2005 Jul 19. Kondera-Anasz, Zdzislawa| Sikora, Justyna| Mielczarek-Palacz, Aleksandra| Jonca, Monika Department of Immunology and Serology, Silesian Medical Academy, Raciborska 15, 40-074 Katowice, Poland. OBJECTIVE: Endometriosis is an immune system-related gynaecological disease, characterised by an increase in number and activation of peritoneal macrophages. One of macrophage-derived factors is interleukin (IL)-1. The effects of IL-1 are inhibited by IL-1 receptor type II (IL-1 RII), soluble forms of IL-1 RII (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra). The aim of our work was to study the IL-1alpha, IL-1 sRII and IL-1 Ra levels in the peritoneal fluid (PF) and serum of women with endometriosis in relation to stage of disease. STUDY DESIGN: Concentrations of IL-1alpha, IL-1 sRII and IL-1 Ra were measured by ELISA assay in the PF and serum of 58 women; 43 with and 15 without endometriosis (control group). RESULTS: Elevated PF and serum IL-1alpha and IL-1 Ra levels in the women with endometriosis in comparison with the control group were observed. IL-1 sRII levels in PF and serum were higher in the controls than in the women with endometriosis. Concentrations of IL-1alpha and IL-1 sRII were higher in advanced endometriosis, but higher IL-1 Ra was observed in the early stage of the disease. CONCLUSION: Impairment of regulation IL-1 activity in the peritoneal fluid and serum of women with endometriosis may play an important role in the pathogenesis and development of the disease. Mesh Terms: Adult| Ascitic Fluid/chemistry| Endometriosis/blood/*complications/surgery| Enzyme-Linked Immunosorbent Assay| Female| Humans| Infertility, Female/blood/*etiology| Interleukin 1 Receptor Antagonist Protein| Interleukin-1/*analysis/blood| Laparosc |
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